Mesenchymal Stem Cells
Introduction
Stem cell therapy is a form of regenerative medicine that utilizes the body’s natural healing mechanism to treat various conditions.
Stem cells are used in regenerative medicine to renew and repair diseased or damaged tissue and have shown promising results in the treatment of various orthopedic, cardiovascular, neuromuscular and autoimmune conditions.
Stem cells are present in all of us acting like a repair system for the body. However, with increasing age, the number of stem cells decline, and the optimum amount of stem cells are not delivered to the injured area. The goal of Stem Cell therapy is to amplify the natural repair system of the patient’s body.
Types of Stem Cells
There are two major types of stem cells: embryonic stem cells and adult stem cells. Embryonic stem cells are stem cells present within the human embryo. This type of stem cell is called pluripotent as it can develop into almost any of the various cell types of the body. Their use in regenerative medicine is however limited due to ethical concerns.
As the embryo develops and forms a baby, stem cells are distributed throughout the body where they reside in specific areas of each tissue, such as the bone marrow and blood. As we age, these cells function to renew old and worn out tissue cells.
Adult stem cells can replicate into more than one cell type, but their replication is restricted to a limited number of cell types. Mesenchymal stem cells are a type of adult stem cell that can replicate into cells that form the musculoskeletal system, such as tendons, ligaments, and articular cartilage.
Use of Stem Cells in Orthopedics
The unique self-regenerating and differentiating ability of mesenchymal stem cells can be used for the repair and regeneration of orthopedic tissues.
These stem cells are commonly obtained from the bone marrow, usually from the iliac crest of the pelvic bone, by inserting a needle to extract the stem cells.
Currently, stem cell therapy is used to treat various degenerative conditions of the shoulder, knees, hips, and spine. They are also being used in the treatment of various soft tissue (muscle, ligaments and tendons) as well as bone-related injuries.
Who is a Good Candidate for a Stem Cell Procedure?
You may be a good candidate for stem cell therapy if you have been suffering from joint pain and want to improve your quality of life while avoiding complications related to invasive surgical procedures.
Preparing for the Procedure
It is important that you stop taking any non-steroidal anti-inflammatory drugs (NSAIDs) at least two weeks before your procedure.
Preparing for a stem cell procedure is relatively easy and your doctor will give you specific instructions depending on your condition.
Stem Cell Procedure
The procedure begins with your doctor extracting stem cells from your own bone marrow. Bone marrow is usually aspirated from your hip region. Your doctor will first clean and numb your hip area. A needle is then introduced into an area of your pelvic bone known as the iliac crest. Bone marrow is then aspirated using a special syringe and the sample obtained is sent to the laboratory. In the laboratory, the aspirate is spun in a machine for 10 to 15 minutes and a concentrated stem cell sample is separated.
Your doctor then cleans and numbs the affected area to be treated and then, under the guidance of special x-rays, injects the stem cells into the diseased region. The whole procedure usually takes less than one hour and you may return home on the same day of the procedure.
Post-Operative Care
You should be able to return to work the next day following your procedure.
You will need to take it easy and avoid any load bearing activities for at least two weeks following your procedure.
You will need to refrain from taking non-steroidal, anti-inflammatory medications (NSAIDs) for a while as this can affect the healing process of your body.
Advantages & Disadvantages
Stem cell therapy is a relatively simple procedure that avoids the complications associated with invasive surgical procedures.
As stem cell therapy uses the cells derived from your own body it reduces the chances of an immune rejection.
Disadvantages
The disadvantage of adult stem cell therapy is lack of data about its long-term effects, as it is a newer evolving therapy.
Risks and Complications
Stem cell therapy is generally considered a safe procedure with minimal complications, however, as with any medical procedure, complications can occur.
Some risks factors related to stem cell therapy include infection as the stem cells may become contaminated with bacteria, viruses or other pathogens that may cause disease during the preparation process.
The procedure to either remove or inject the cells also has a small risk of introducing an infection to the damaged tissue into which they are injected. Rarely, an immune reaction may occur from injected stem cells.
Summary
Stem cell therapy is a procedure being used in the treatment of a variety of medical conditions and has shown significant results in restoring mobility and improving quality of life in many patients.
